解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The guanidyl moiety is a component of fundamental metabolites, including the amino acid arginine, the energy carrier creatine, and the nucleobase guanine. Curiously, reports regarding the importance of free guanidine in biology are sparse, and no biological receptors that specifically recognize this compound have been...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.11.019
更新日期:2017-01-19 00:00:00
abstract::In mammalian cells, histone deacetylase (HDAC) and Sirtuin (SIRT) are two families responsible for removing acetyl groups from acetylated proteins. Here, we describe protein deacetylation coupled with deacetylimination as a function of lysyl oxidase (LOX) family members. LOX-like 3 (Loxl3) associates with Stat3 in the...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.12.002
更新日期:2017-01-19 00:00:00
abstract::TET proteins, by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), are hypothesized, but not directly shown, to protect promoter CpG islands (CGIs) against abnormal DNA methylation (DNAm) in cancer. We define such a protective role linked to DNA damage from oxidative stress (OS) known to induce this...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.12.013
更新日期:2017-01-19 00:00:00
abstract::Nonsense-mediated decay (NMD) degrades mRNAs containing a premature termination codon (PTC). PTCs are a frequent cause of human genetic diseases, and the NMD pathway is known to modulate disease severity. Since partial NMD attenuation can potentially enhance nonsense suppression therapies, better definition of human-s...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.11.032
更新日期:2017-01-05 00:00:00
abstract::Repetitive DNA elements are essential for genome function; in this issue of Molecular Cell, Ishak et al. (2016) describe a novel mechanism of epigenetic repression at these elements that requires pRB-dependent recruitment of EZH2. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2016.11.035
更新日期:2016-12-15 00:00:00
abstract::The methylcytosine oxidase TET proteins play important roles in DNA demethylation and development. However, it remains elusive how exactly they target substrates and execute oxidation. Interestingly, we found that, in mice, the full-length TET1 isoform (TET1e) is restricted to early embryos, embryonic stem cells (ESCs...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.10.030
更新日期:2016-12-15 00:00:00
abstract::Bacteria commonly exist in high cell density populations, making them prone to viral predation and horizontal gene transfer (HGT) through transformation and conjugation. To combat these invaders, bacteria possess an arsenal of defenses, such as CRISPR-Cas adaptive immunity. Many bacterial populations coordinate their ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.11.012
更新日期:2016-12-15 00:00:00
abstract::The Mre11-Rad50-Xrs2 (MRX) complex is related to SMC complexes that form rings capable of holding two distinct DNA strands together. MRX functions at stalled replication forks and double-strand breaks (DSBs). A mutation in the N-terminal OB fold of the 70 kDa subunit of yeast replication protein A, rfa1-t11, abrogates...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.10.032
更新日期:2016-12-01 00:00:00
abstract::Distinctive from their normal counterparts, cancer cells exhibit unique metabolic dependencies on glutamine to fuel anabolic processes. Specifically, pancreatic ductal adenocarcinoma (PDAC) cells rely on an unconventional metabolic pathway catalyzed by aspartate aminotransferase, malate dehydrogenase 1 (MDH1), and mal...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.09.028
更新日期:2016-11-17 00:00:00
abstract::The eukaryotic RNA exosome is an essential and conserved 3'-to-5' exoribonuclease complex that degrades or processes nearly every class of cellular RNA. The nuclear RNA exosome includes a 9-subunit non-catalytic core that binds Rrp44 (Dis3) and Rrp6 subunits to modulate their processive and distributive 3'-to-5' exori...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.09.038
更新日期:2016-11-17 00:00:00
abstract::The Mre11/Rad50/Nbs1 complex initiates double-strand break repair by homologous recombination (HR). Loss of Mre11 or its nuclease activity in mouse cells is known to cause genome aberrations and cellular senescence, although the molecular basis for this phenotype is not clear. To identify the origin of these defects, ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.10.011
更新日期:2016-11-03 00:00:00
abstract::Polyubiquitin chains of different topologies regulate diverse cellular processes. K48- and K63-linked chains, the two most abundant chain types, regulate proteolytic and signaling pathways, respectively. Although recent studies reported important roles for heterogeneous chains, the functions of branched ubiquitin chai...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.09.014
更新日期:2016-10-20 00:00:00
abstract::RNA sequence motifs are not sufficient for association with RBPs. In this issue of Molecular Cell, Taliaferro et al. (2016) demonstrate that, other than sequence motif, RNA secondary structure plays a repressive role on RBP binding, both in vitro and in vivo. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2016.10.006
更新日期:2016-10-20 00:00:00
abstract::The anaphase-promoting complex or cyclosome (APC/C) is a ubiquitin ligase that polyubiquitinates specific substrates at precise times in the cell cycle, thereby triggering the events of late mitosis in a strict order. The robust substrate specificity of the APC/C prevents the potentially deleterious degradation of non...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2016.09.006
更新日期:2016-10-06 00:00:00
abstract::While much research has examined the use of glucose and glutamine by tumor cells, many cancers instead prefer to metabolize fats. Despite the pervasiveness of this phenotype, knowledge of pathways that drive fatty acid oxidation (FAO) in cancer is limited. Prolyl hydroxylase domain proteins hydroxylate substrate proli...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.08.014
更新日期:2016-09-15 00:00:00
abstract::In bacteria, RNA polymerase (RNAP) initiates transcription by synthesizing short transcripts that are either released or extended to allow RNAP to escape from the promoter. The mechanism of initial transcription is unclear due to the presence of transient intermediates and molecular heterogeneity. Here, we studied ini...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.08.011
更新日期:2016-09-15 00:00:00
abstract::Identifying DNA fragile sites is crucial to reveal hotspots of genomic rearrangements, yet their precise mapping has been a challenge. A new study in this issue of Molecular Cell (Canela et al., 2016) introduces a highly sensitive and accurate method to detect DNA breaks in vivo that can be adapted to various experime...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2016.08.012
更新日期:2016-09-01 00:00:00
abstract::DNA double-strand breaks (DSBs) arise during physiological transcription, DNA replication, and antigen receptor diversification. Mistargeting or misprocessing of DSBs can result in pathological structural variation and mutation. Here we describe a sensitive method (END-seq) to monitor DNA end resection and DSBs genome...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.06.034
更新日期:2016-09-01 00:00:00
abstract::Prokaryotes use a mechanism called priming to update their CRISPR immunological memory to rapidly counter revisiting, mutated viruses, and plasmids. Here we have determined how new spacers are produced and selected for integration into the CRISPR array during priming. We show that Cas3 couples CRISPR interference to a...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.07.011
更新日期:2016-09-01 00:00:00
abstract::Upon heterologous overexpression, many proteins misfold or aggregate, thus resulting in low functional yields. Human acetylcholinesterase (hAChE), an enzyme mediating synaptic transmission, is a typical case of a human protein that necessitates mammalian systems to obtain functional expression. We developed a computat...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.06.012
更新日期:2016-07-21 00:00:00
abstract::The RNA exosome complex associates with nuclear and cytoplasmic cofactors to mediate the decay, surveillance, or processing of a wide variety of transcripts. In the cytoplasm, the conserved core of the exosome (Exo10) functions together with the conserved Ski complex. The interaction of S. cerevisiae Exo10 and Ski is ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.05.028
更新日期:2016-07-07 00:00:00
abstract::Maintaining a fluid bilayer is essential for cell signaling and survival. Lipid saturation is a key factor determining lipid packing and membrane fluidity, and it must be tightly controlled to guarantee organelle function and identity. A dedicated eukaryotic mechanism of lipid saturation sensing, however, remains elus...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.05.015
更新日期:2016-07-07 00:00:00
abstract::Never-in-mitosis A-related kinase 1 (Nek1) has established roles in apoptosis and cell cycle regulation. We show that human Nek1 regulates homologous recombination (HR) by phosphorylating Rad54 at Ser572 in late G2 phase. Nek1 deficiency as well as expression of unphosphorylatable Rad54 (Rad54-S572A) cause unresolved ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.04.032
更新日期:2016-06-16 00:00:00
abstract::Ubiquitination typically occurs through the sequential action of three enzymes catalyzing ubiquitin activation (E1), conjugation (E2), and ligation (E3) and regulates diverse eukaryotic cellular processes. Although monoubiquitination commonly confers nondegradative activities, mechanisms underlying its temporal and sp...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.04.022
更新日期:2016-06-16 00:00:00
abstract::How eukaryotic chromosomes fold inside the nucleus is an age-old question that remains unanswered today. Early biochemical and microscopic studies revealed the existence of chromatin domains and loops as a pervasive feature of interphase chromosomes, but the biological implications of such organizational features were...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2016.05.018
更新日期:2016-06-02 00:00:00
abstract::The majority of the human genome is transcribed into non-coding (nc)RNAs that lack known biological functions or else are only partially characterized. Numerous characterized ncRNAs function via base pairing with target RNA sequences to direct their biological activities, which include critical roles in RNA processing...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.04.030
更新日期:2016-05-19 00:00:00
abstract::Histone H2B monoubiquitination (H2Bub1) is centrally involved in gene regulation. The deubiquitination module (DUBm) of the SAGA complex is a major regulator of global H2Bub1 levels, and components of this DUBm are linked to both neurodegenerative diseases and cancer. Unexpectedly, we find that ablation of USP22, the ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.03.030
更新日期:2016-05-19 00:00:00
abstract::Deubiquitinating enzymes (DUBs) recognize and cleave linkage-specific polyubiquitin (polyUb) chains, but mechanisms underlying specificity remain elusive in many cases. The severe acute respiratory syndrome (SARS) coronavirus papain-like protease (PLpro) is a DUB that cleaves ISG15, a two-domain Ub-like protein, and L...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.04.016
更新日期:2016-05-19 00:00:00
abstract::Epitranscriptomic marks are dynamically placed on mRNA by "writer" or "eraser" enzymes, while "readers" modulate their function accordingly. Lin et al. (2016) now report that the N6-methyladenosine:RNA methyltransferase METTL3 is both a writer and a reader, directly enhancing mRNA translation. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2016.04.024
更新日期:2016-05-05 00:00:00
abstract::The RSC chromatin remodeler slides and ejects nucleosomes, utilizing a catalytic subunit (Sth1) with DNA translocation activity, which can pump DNA around the nucleosome. A central question is whether and how DNA translocation is regulated to achieve sliding versus ejection. Here, we report the regulation of DNA trans...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.03.032
更新日期:2016-05-05 00:00:00
abstract::We report the identification of histone PARylation factor 1 (HPF1; also known as C4orf27) as a regulator of ADP-ribosylation signaling in the DNA damage response. HPF1/C4orf27 forms a robust protein complex with PARP-1 in cells and is recruited to DNA lesions in a PARP-1-dependent manner, but independently of PARP-1 c...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.03.008
更新日期:2016-05-05 00:00:00
abstract::PRDM16 is a transcription co-factor that plays critical roles in development of brown adipose tissue, as well as maintenance of adult hematopoietic and neural stem cells. Here we report that PRDM16 is a histone H3K4 methyltransferase on chromatin. Mutation in the N-terminal PR domain of PRDM16 abolishes the intrinsic ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.03.010
更新日期:2016-04-21 00:00:00
abstract::In this issue of Molecular Cell, Gross et al. (2016) find a CpG DNA methylation signature in blood cells of patients with chronic well-controlled HIV infection that correlates with accelerated aging. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2016.04.008
更新日期:2016-04-21 00:00:00
abstract::The control of mRNA stability plays a central role in regulating gene expression. In metazoans, the earliest stages of development are driven by maternally supplied mRNAs. The degradation of these maternal mRNAs is critical for promoting the maternal-to-zygotic transition of developmental programs, although the underl...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.02.027
更新日期:2016-03-17 00:00:00
abstract::Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system in prokaryotes. The system preserves memories of prior infections by integrating short segments of foreign DNA, termed spacers, into the CRISPR array in a process termed adaptati...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2016.01.030
更新日期:2016-03-17 00:00:00
abstract::A decline in mitochondrial quality and activity has been associated with normal aging and correlated with the development of a wide range of age-related diseases. Here, we review the evidence that a decline in mitochondria function contributes to aging. In particular, we discuss how mitochondria contribute to specific...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2016.01.028
更新日期:2016-03-03 00:00:00
abstract::Centromeres are specialized chromatin domains specified by the centromere-specific CENP-A nucleosome. The stable inheritance of vertebrate centromeres is an epigenetic process requiring deposition of new CENP-A nucleosomes by HJURP. We show HJURP is recruited to centromeres through a direct interaction between the HJU...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.02.014
更新日期:2016-03-03 00:00:00
abstract::XPG is a structure-specific endonuclease required for nucleotide excision repair, and incision-defective XPG mutations cause the skin cancer-prone syndrome xeroderma pigmentosum. Truncating mutations instead cause the neurodevelopmental progeroid disorder Cockayne syndrome, but little is known about how XPG loss resul...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2015.12.026
更新日期:2016-02-18 00:00:00
abstract::Recent studies, including two in this issue of Molecular Cell (Elbatsh et al., 2016; Beckouët et al., 2016), cast light on how cohesin regulators harness the energy of ATP hydrolysis to open the cohesin ring and enable dynamic, regulated entrapment of chromosomes. ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.02.003
更新日期:2016-02-18 00:00:00
abstract::Nucleolytic resection of DNA double-strand breaks is the crucial first step in their repair via homologous recombination. New findings by Tkáč et al. (2016) published in this issue of Molecular Cell identify HELB as a novel, cell-cycle-specific negative regulator of DNA end resection. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2016.01.022
更新日期:2016-02-04 00:00:00